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Dear readers,
Once
again, we hope to provide you with an interesting
e-Journal, which I’m quite sure you will enjoy
reading. A challenging article from Defrère
et al from Professor Donnez’s group reports
on the possible involvement of iron in the pathogenesis
of peritoneal endometriosis. Iron overload, retrograde
menstruations, lysis of erythrocytes and possible
involvement of activated peritoneal macrophages,
iron uptake and increased proliferation of endometrial
cells are all supportive of a possible involvement
in endometriosis
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Professor Ali Akoum
WES e-Journal editor |
pathophysiology. The fact
that an iron chelator, desferrioxamine, reduced
the iron-induced cell proliferation in vivo is interesting,
provoking and argumentative.
The papers published in the e-Journal are open for
discussion and debate! Send us your comments, thoughts
and any articles you may wish to reach a
great number of interested people via the WES’s
special and practical channel. In the second article,
Dr Bondza et al provide us with an interesting literature
review of the role of endometrial dysfunctions in
endometriosis pathogenesis. Aberrantly expressed
hormonal, immuno-inflammatory, tissue remodelling,
apoptotic and angiogenic factors may play a central
role in endometriosis pathogenesis and related symptoms.
Every day we learn
more about this enigmatic disease thanks to the
efforts of a great number of researchers throughout
the world. Our common challenge will be to translate
these findings into sustainable improvements of
endometriosis diagnosis and clinical outcomes. I
thank the authors for their appreciated contribution
and we are looking forward to receiving yours! You
are kindly invited to react to these articles or
to any other issue that may stimulate constructive
exchange.
Do not miss the highlights from the PAX meeting
in Leuven, Belgium, the update on WCE 2008 in Australia
and all you may wish to know about the Aussie’s
traditions, getting that air fare, and the current
amusing and enlightening “10 sex facts in
Australia”… Stay tuned!
Sincerely,
Ali Akoum
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